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Blogs I Follow
Daily Archives: October 26, 2012
Characterization of Novel Glutathione Adducts of a Non-Nucleoside Reverse Transcriptase Inhibitor, (S)-6-Chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-3,4-dihydro-2(1H)-quinazolinone (DPC 961), in Rats. Possible Formation of an Oxirene Metabolic Intermediate from a Disubstituted Alkyne by Abdul Mutlib CRT 2000
Mutlib, A., et al. Chem. Res. Toxicol., 2000, 13 (8), pp 775–784 I would like to post a number of classical papers on MetID and biotransformation pathway elucidation. The first one is Abdul Mutlib’s work on an anti-HIV drug, DPC 961 published some years ago, using LC-MS, NMR and … Continue reading →
ADMETchemist 