-
Join 20 other subscribers
Categories
- ADME
- Bioactivation
- Biotransformation
- Blood Brain Barrier
- Carcinogens
- Central Nervous System (CNS)
- Chemistry
- Company
- Conjugation Reactions
- Covalent Binding
- Cytochrome P450
- Definitions
- Disease
- DNA Adducts
- Drug Design
- Drug Drug Interaction (DDI)
- Drug Metabolism
- Drug Safety
- Drug Target
- Drugs
- Heterocycles
- Human Liver Microsomes(HLM)
- Idiosyncratic Effect
- Immune Response
- In Vitro/In Vivo Correlation
- Introduction
- Mass Spectrometry
- Mechanism-Based Inhibition (MBI)
- Med Chem
- Metabolic Stability
- Metabolite Identification (MetID)
- Metabolite Prediction
- Metabolite Profiling
- Metabolomics
- Mutagens
- Natrual Products
- Non-P450 enzymes
- P450 Phenotyping
- Pharmacokinetics (PK)
- Phase 2 Metabolism
- Physicochemical Properties
- Protein Adducts
- Radioisotope Label
- Reactive Intermediates
- SAR
- Solvent Effects
- Time-dependent Inhibition (TDI)
- Toxicity
- Uncategorized
Recently Viewed Posts
- Metabolically Stable tert-Butyl Replacement ACS Med Chem Lett 2013
- Deuterated Clopidogrel Analogues as a New Generation of Antiplatelet Agents ACS Med Chem Lett 2013
- Thiolactone Sulfoxides as New Reactive Metabolites Acting as Bis-Electrophiles: Implication in Clopidogrel and Prasugrel Bioactivation CRT 2013
- Which Metabolites Circulate? Minireview DMD 2013
- Boronic Acid-Containing Proteasome Inhibitors: Alert to Potential Pharmaceutical Bioactivation CRT 2013
Blogs I Follow
Monthly Archives: November 2012
Identifying a Selective Substrate and Inhibitor Pair for the Evaluation of CYP2J2 Activity DMD 2012
Lee, C. A., et al. Drug Metab. Dispos. May 2012 40:943-951
Reactive Intermediates Produced from the Metabolism of the Vanilloid Ring of Capsaicinoids by P450 Enzymes CRT 2012
Reilly, C. A., et al. Chem. Res. Toxicol., Article ASAP
Posted in 1A2, 2C19, 2D6, 3A4, Bioactivation, Biotransformation, Capsaicinoids, Glutathione (GSH) Adducts, Human Liver Microsomes(HLM), P450 Phenotyping, Quinone, Quinone Methide, Reactive Intermediates
Tagged Bioactivation, Biotransformation, Capsaicinoids, Qunione, Qunione-methide, Reactive Intermediates, Toxicity
Leave a comment
Deoxyguanosine Forms a Bis-Adduct with E,E-Muconaldehyde, an Oxidative Metabolite of Benzene: Implications for the Carcinogenicity of Benzene CRT 2011
Harris, C. M., et al. Chem. Res. Toxicol., 2011, 24 (11), pp 1944–1956
Polyamines Are Traps for Reactive Intermediates in Furan Metabolism CRT 2011
Peterson, L. A., et al. Chem. Res. Toxicol., 2011, 24 (11), pp 1924–1936
Posted in Biotransformation, Furan, Polyamine
Tagged Biotransformation, Furan, Polyamine
Leave a comment
Chemical and Enzymatic Reductive Activation of Acylfulvene to Isomeric Cytotoxic Reactive Intermediates CRT 2011
Pietsch, K. E., et al. Chem. Res. Toxicol., 2011, 24 (11), pp 2044–2054
Posted in Acylfulvene, Bioactivation, DNA Adducts
Tagged Acylfulvene, Bioactivation, DNA Adducts
Leave a comment
Novel Cytochrome P450 Bioactivation of a Terminal Phenyl Acetylene Group: Formation of a One-Carbon Loss Benzaldehyde and Other Oxidative Products in the Presence of N-Acetyl Cysteine or Glutathione CRT 2011
Subramanian, R., et al. Chem. Res. Toxicol., 2011, 24 (5), pp 677–686
Posted in Acetylene, Bioactivation
Tagged Acetylene, Bioactivation, Glutathione (GSH) Adducts
Leave a comment
Cross-Linking of Dithiols by Mitomycin C CRT 2010
Paz, M. M., Chem. Res. Toxicol., 2010, 23 (8), pp 1384–1392
ADMETchemist 