-
Join 20 other subscribers
Categories
- ADME
- Bioactivation
- Biotransformation
- Blood Brain Barrier
- Carcinogens
- Central Nervous System (CNS)
- Chemistry
- Company
- Conjugation Reactions
- Covalent Binding
- Cytochrome P450
- Definitions
- Disease
- DNA Adducts
- Drug Design
- Drug Drug Interaction (DDI)
- Drug Metabolism
- Drug Safety
- Drug Target
- Drugs
- Heterocycles
- Human Liver Microsomes(HLM)
- Idiosyncratic Effect
- Immune Response
- In Vitro/In Vivo Correlation
- Introduction
- Mass Spectrometry
- Mechanism-Based Inhibition (MBI)
- Med Chem
- Metabolic Stability
- Metabolite Identification (MetID)
- Metabolite Prediction
- Metabolite Profiling
- Metabolomics
- Mutagens
- Natrual Products
- Non-P450 enzymes
- P450 Phenotyping
- Pharmacokinetics (PK)
- Phase 2 Metabolism
- Physicochemical Properties
- Protein Adducts
- Radioisotope Label
- Reactive Intermediates
- SAR
- Solvent Effects
- Time-dependent Inhibition (TDI)
- Toxicity
- Uncategorized
Recently Viewed Posts
- Metabolically Stable tert-Butyl Replacement ACS Med Chem Lett 2013
- Deuterated Clopidogrel Analogues as a New Generation of Antiplatelet Agents ACS Med Chem Lett 2013
- Thiolactone Sulfoxides as New Reactive Metabolites Acting as Bis-Electrophiles: Implication in Clopidogrel and Prasugrel Bioactivation CRT 2013
- Which Metabolites Circulate? Minireview DMD 2013
- Boronic Acid-Containing Proteasome Inhibitors: Alert to Potential Pharmaceutical Bioactivation CRT 2013
Blogs I Follow
Daily Archives: October 8, 2012
Effect of Structural Variation on Aldehyde Oxidase-Catalyzed Oxidation of Zoniporide by Deepak Dalvie et al. from Pfizer DMD 2012
Deepak, D., et al. Drug Metab Dispos. 2012 Aug;40(8):1575-87. Epub 2012 May 15. A nice paper on structural effects of substrates on aldehyde oxidase-catalyzed oxidation.
Posted in Aldehyde Oxidase, Bioactivation, Drug Metabolism, Heterocycles, SAR
|
Tagged Aldehyde Oxidase (AO), Bioactivation, Drug Metabolism, Heterocycles, Reactive Intermediates, SAR
|
Leave a comment