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Blogs I Follow
Tag Archives: Quinone Methide
Oxidative ipso Substitution of 2,4-Difluoro-benzylphthalazines: Identification of a Rare Stable Quinone Methide and Subsequent GSH Conjugate from Novartis DMD 2012
Gunduz, M., et al. Drug Metab. Dispos. 2012 Nov;40(11):2074-80 An interesting paper just came out from NIBR on DMD. 1. Two fluorine atoms was not able to block the P450-involved metabolism. Instead, an oxidative ipso substitution occurs with the loss of a fluorine atom. … Continue reading →
ADMETchemist 