Gunduz, M., et al. Drug Metab. Dispos. 2012 Nov;40(11):2074-80
An interesting paper just came out from NIBR on DMD.
1. Two fluorine atoms was not able to block the P450-involved metabolism.
Instead, an oxidative ipso substitution occurs with the loss of a fluorine atom.
2. A resonance-stabilized quinone methide metabolite was identified.
ADMETchemist 